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. 2024 May 10;45:101977. doi: 10.1016/j.tranon.2024.101977

Fig. 8.

Fig 8

The radioresistant effect of HMGB2 in gliomas. (A)HMGB2-SI and (B)HMGB2-OE cells separately displayed weaker and stronger colony formation capability than control groups under the same radiation dose, the representative colony images of U251 and U87 cells exposed to 0, 2, 4,6,8,10 Gy were given. clonogenic survivals of (C)U251 and (D)U87 cells with HMGB2 knockdown and overexpression.SF2 of (E)U251 and (F)U87 cells. Images of γ-H2AX foci formed in (H)U87 cells and (G)U251 cells at 0.5 h, 2 h, 6 h and 24 h after 5 Gy radiation. Histogram of γ-H2AX foci number in (J)U87 and (I)U251 cells. D0,mean lethal dose; Dq,quasi-threshold dose; SF2,surviving fraction at 2 Gy; N,extrapolation number; SER,sensitization enhancement ratio. *p < 0.05, **p < 0.01, ***p < 0.001,****p < 0.0001.