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. 2024 May 9;45:101979. doi: 10.1016/j.tranon.2024.101979

Fig. 2.

Fig 2

RBP4 expression in HCC serum and tissue samples. (A) Relative expression of RBP4 protein in serum as verified by MRM. a, compared with HC, P < 0.0001; b, compared with CHB, P < 0.001. (B) Representative images (400 ×) of positive RBP4 staining in HCC tissues (right panel) and negative staining in adjacent non-tumorous liver tissues (left panel) by IHC staining. Differential expression of RBP4 between (C) cancerous and adjacent non-tumorous tissues (P < 0.0001) of HCC patients, and between (D) cancerous tissues of AFP-negative (serum AFP < 25 ng/mL) and AFP-positive (serum AFP = 25–400 ng/mL and AFP >400 ng/mL) HCC patients (P < 0.01) based on semi-quantification of RBP4 IHC. HC, healthy controls; CHB, chronic hepatitis B virus infection; LC, liver cirrhosis; HCC, hepatocellular carcinoma.