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. 2024 May 9;45:101979. doi: 10.1016/j.tranon.2024.101979

Fig. 3.

Fig 3

Serum concentrations of RBP4 by ELISA and receiver operating characteristic (ROC) curve analysis of diagnostic value (A) Serum levels of RBP4 were measured by ELISA in patients with HCC, CHB and healthy controls. a, compared with HC, P < 0.001; b, compared with CHB, P < 0.001. ROC curves for (B) RBP4 alone and RBP4 combined with AFP for all HCC patients versus HC (a, RBP4, AUC = 0.931, 95 % CI: 0.911∼0.950; b, RBP4+AFP, AUC = 0.954, 95 % CI: 0.939∼0.970,R, reference line), (C) AFP negative HCC versus healthy controls (AUC = 0.923, 95 % CI: 0.897∼0.948), (D) AFP positive HCC versus healthy controls (AUC = 0.942, 95 %CI: 0.921∼0.963), (E) RBP4 alone and RBP4 combined with AFP for all HCC patients versus all controls (a, RBP4, AUC = 0.879, 95 % CI: 0.854∼0.903; b,RBP4+AFP, AUC = 0.919, 95 % CI: 0.898∼0.940), (F)AFP negative HCC versus all controls (AUC = 0.875, 95 % CI: 0.843∼0.906) and (G) AFP positive HCC versus all controls (AUC = 0.884, 95 % CI: 0.855∼0.913). (H) CHB versus all HCC (a, RBP4, AUC = 0.809; 95 % CI: 0.771–0.846; b, RBP4+AFP, AUC = 0.872, 95 % CI: 0.840∼0.903; c, AFP, AUC = 0.689, 95 % CI: 0.643∼0.735) (I) Proportion of positive results for AFP, RBP4 or both in patients with HCC. The cutoff value of RBP4 was determined by area under receiver operating characteristic curve (cutoff = 14.06 μg/mL). AFP positive, AFP > 25 ng/mL; AFP negative, AFP < 25 ng/mL; RBP4 positive, RBP4 < 14.06 μg/mL; RBP4 negative, RBP4 > 14.06 μg/mL.