Table 4.
Results for measurement of serum RBP4, AFP, or both * in the diagnosis of HCC.
| AUC# (%) | 95% CI | Sensitivity (%) | Specificity (%) | Youden's index (%) | |
|---|---|---|---|---|---|
| HCC vs HC+CHB | |||||
| RBP4 | 87.9 | 85.4∼90.3 | 80.3 | 80.9 | 61.2 |
| AFP | 69.7 | 65.6∼73.8 | 40.7 | 98.7 | 39.4 |
| RBP4+AFP | 91.9 | 89.8∼94.0 | 87.9 | 80.0 | 67.9 |
| HCC (AFP-) vs HC+CHB | |||||
| RBP4 | 87.5 | 84.3∼90.6 | 79.5 | 80.7 | 60.4 |
| HCC (AFP+) vs HC+CHB | |||||
| RBP4 | 88.4 | 85.5∼91.3 | 81.4 | 80.7 | 62.2 |
| HCC vs CHB | |||||
| RBP4 | 80.9 | 77.2∼84.7 | 80.3 | 68.3 | 48.6 |
| AFP | 68.9 | 64.3∼73.5 | 40.8 | 97.0 | 37.9 |
| RBP4+AFP | 87.2 | 84.0∼90.3 | 81.0 | 82.7 | 63.6 |
RBP4, retinol-binding protein 4; AFP, alpha-fetoprotein; HCC, Hepatocellular carcinoma; HC, healthy controls; CHB, chronic hepatitis B virus infection; AUC, area under the ROC curve. *, The diagnostic cutoff values for serum RBP4 and AFP were 14.06 μg/mL and 25 ng/mL respectively. # P < 0.05 by ROC curve analysis compared to the reference AUC.