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a Transcription factors and cis-regulatory regions/elements in the Mesp1 gene. b A Tcf/Lef-Oct4 composite site mediates cell fate decisions. It recruits Oct4 and Sox2 to the cis-regulatory regions of pluripotent genes and maintains undifferentiated state. It mediates the converge of Oct4 and canonical Wnt signaling, thus spatially and temporally restricts Mesp1 expression
