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Dynamic regulation upon a Wnt/beta-catenin/Mesp1 cascade in cardiomyocyte differentiation. The cascade of Wnt/beta-catenin/Mesp1 is required in gastrulation, generating the cardiac and hemogenic mesoderm. While the further differentiation of the cardiac mesoderm into ECs and SMCs may be independent from the cascade, active shutdown of the cascade is required for CM formation
