Fig. 2.

Protein complexes of PTEN generate new PTEN proteoforms. a The co-crystal structure of the PTEN–PDZ-binding domain with the PDZ-binding domain of MAST2 demonstrates that the disordered PTEN–PDZ-binding domain adopts a secondary structure primarily comprising a β-strand, a turn, and a bend. b In contrast, the PTEN–PDZ-binding domain adopts a slightly different secondary structure, comprising a β-strand and a bend, in complex with Par3