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Post-translational modifications of PTEN generates a set of PTEN proteoforms. PTEN undergoes several post-translational modifications that control its catalytic activity, stability, sub-cellular localization, and ability to engage in protein–protein interactions. (Ub ubiquitination, P phosphorylation, O oxidation, N nitrosylation, Rib ribosylation, Su sumoylation, Me methylation, Ac acetylation). Each of these modified PTEN proteins is considered a novel proteoform
