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Translational variants of PTEN. PTEN has four reported translational variants, PTEN-L, -M, -N, and -O that are produced due to alternative translational initiation. Translation begins from an upstream non-AUG codon resulting in N-terminal extensions for each of the variants. It is likely that each of these proteoforms may behave differently in terms of their function and sub-cellular routing, trafficking, and localization
