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Effector functions of IgG antibodies. In addition to neutralization initiated by binding of the Fab domain to target molecules, the antibodies’ Fc fragment mediates IgG effector functions such as killing of transformed cells or bacteria by opsonization, antibody-dependent cell-mediated cytotoxicity (ADCC), antibody-dependent cell-mediated phagocytosis (ADCP) or complement-dependent cytotoxicity (CDC)
