Fig. 6.

Homozygous hIAPP-Tg animals. a Kaplan–Meier curves for mouse survival. Hemizygous hIAPP-Tg^+/− mice were taken as controls. hIAPP-Tg^+/+xBACE2^−/− presented a higher survival rate than hIAPP-Tg^+/+BACE2^+/+. b Follow-up of fed plasma glucose levels in the three experimental groups. All curves were started with at least 20 animals per group. c Representative images of insulin (green) and glucagon (red) immunostaining from whole pancreas slices with differentiating β-cell area between the hIAPP-Tg^+/+ and hIAPP-Tg^+/+xBACE2^−/−. Nuclei stained with Hoechst (blue). Bar scale 50 µm