Fig. 7.

Structural and aggregation properties of W41F and W79F-M-TTR mutants. a Far-UV CD spectra of the non-mutated and mutant forms of M-TTR obtained in 20 mM phosphate buffer, pH 7.4, 25 °C. b Size distributions by DLS of unlabelled and labelled non-mutated, W79F- and W41F-M-TTR at pH 7.4, 25 °C. c Aggregation time courses of W41F-M-TTR at pH 7.4, 37 °C in the presence of 0–137 mM NaCl