Table 1.

Data collection and refinement statistics for DACM-WT-TTR and DACM-M-TTR

Crystala	DACM-WT-TTR	DACM-M-TTR
Space group	P 21221	P 212121
Unit cell constants (Å)	a = 43.68, b = 64.49, c = 85.27 α, β, γ = 90 °C	a = 64.44, b = 83.76, c = 86.53 α, β, γ = 90 °C
Resolution (Å)	22.35–1.42 (1.50–1.42)	22.04–1.70 (1.79–1.70)
R merge (%)b	9.7 (73.0)	11.1 (77.2)
I/σI	8.1 (2.1)	8.1 (1.9)
Completeness (%)	99.1 (99.2)	99.5 (99.8)
Multiplicity	5.0 (5.0)	4.1 (4.3)
Molecules per asymmetric unit	2	4
Refinement
R work (%)c	16.0	15.0
R free (%)	21.7	22.3
Ramachandran plot, n (residues)
Most favored region	200	421
Allowed region	3	8
Outliers	0	2
RMSDd	0.31 Å 114/114 Cα	0.60 Å 115/115 Cα

^aValues given in parenthesis refer to the high-resolution shell

^b R _merge = Σhkl ΣjIhkl,j − $〈Ihkl〉$/ΣhklΣjIhkl,j where I is the observed intensity and $〈I〉$ is the average intensity

^c R _work = ΣhklFo − Fc/ΣhklFo for all data except 5–10%, which were used for the R _free calculation

^dRMSD values calculated from the structural superposition of the DACM-WT-TTR and DACM-M-TTR structures with the non-labeled WT-TTR (pdb code: 1BMZ) and M-TTR (pdb code: 1GKO)