Table 2.

Comparison of human and murine MSCs

Items	Human MSCs	Murine MSCs
Differences in specific markers	Stro-1, CD146, alkaline phosphatase, CD49a, CD271, and HLA-DR [3, 8]	Nestin, CD105, vascular cell adhesion protein, CD90, MHCII [5, 19, 46]
Common markers	Positive: Sca-1, CD105, CD73, CD29, and CD44 Negative: CD45, CD34, CD11b, CD31, and MHCII [3, 5, 8, 19, 46]
Differences in effector molecules for immune regulation	IDO, HLA-G5 [35, 47, 50]	NO [47, 50]
Common effector molecules for immune regulation	PGE2, IL-6, IL-10, TGFβ, TSG-6, CCL2, IL-1Ra [30, 39, 69–71, 80, 82, 83]
Key cytokines for induction of immunosuppressive capacity	IFN-γ and TNF-α [43, 47]	IFN-γ [43]