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. 2017 Mar 17;74(15):2773–2782. doi: 10.1007/s00018-017-2497-x

Table 1.

Selected small molecules that inhibit the HH signaling

Structure Name Target References
graphic file with name 18_2017_2497_Figa_HTML.gif RUSKI-43 SHH ligand [56]
graphic file with name 18_2017_2497_Figb_HTML.gif RUSKI-201 SHH ligand [62]
graphic file with name 18_2017_2497_Figc_HTML.gif Cyclopamine SMO [63]
graphic file with name 18_2017_2497_Figd_HTML.gif KAAD-cyclopamine SMO [64]
graphic file with name 18_2017_2497_Fige_HTML.gif IPI-926 (Saridegib) SMO [71]
graphic file with name 18_2017_2497_Figf_HTML.gif Vismodegib (GDC-0449) SMO

[76]

[77]
graphic file with name 18_2017_2497_Figg_HTML.gif PF-04449913 (Glasdegib) SMO [81]
graphic file with name 18_2017_2497_Figh_HTML.gif LY2940680 (Taladegib) SMO

[86]

[87]
graphic file with name 18_2017_2497_Figi_HTML.gif Sonidegib (LDE-225) SMO

[76]

[77]
graphic file with name 18_2017_2497_Figj_HTML.gif GANT58 GLI [92]
graphic file with name 18_2017_2497_Figk_HTML.gif GANT61 GLI [92]
graphic file with name 18_2017_2497_Figl_HTML.gif HPI-1 GLI [97]
graphic file with name 18_2017_2497_Figm_HTML.gif HPI-2 GLI [97]
graphic file with name 18_2017_2497_Fign_HTML.gif HPI-3 GLI [97]
graphic file with name 18_2017_2497_Figo_HTML.gif HPI-4 Ciliogenesis [97]
graphic file with name 18_2017_2497_Figp_HTML.gif Arsenic trioxide GLI

[98]

[99]