Table 3.
In vivo anticancer activity of α-helical and β-sheet cationic antimicrobial peptides
| Peptide class | Species/species derived from | Peptide name | In vivo model(s) used | Effects/proposed mechanisms | Reference[s] |
|---|---|---|---|---|---|
| α-Helical | |||||
| Cathelicidin | Snake (Bungarus fasciatus) | BF-30 | B16F10 mouse allograft model | Suppression of tumor growth | [104] |
| Magainin | African claw frog (X. laevis) | Magainin II (MG2), MSI-136, MSI-238 (MG2 derivatives) | P388/L1210, S180 and SOT mouse allograft models | Increased lifespan, tumor shrinkage | [48] |
| African claw frog (X. laevis), European fire-bellied toad. (Bombina bombina) | MG2B (MG2-Bombesin conjugate) | MCF-7 mouse xenograft model | Suppression of tumor growth | [52] | |
| African claw frog (X. laevis), Drosophila | MG2A (MG2-penetratin conjugate) | HeLa, A549 mouse xenograft model | Suppression of tumor growth (necrosis) | [108] | |
| Buforin | Asian toad (B. gargarizans) | Buforin IIb | NCI-H460 mouse xenofraft model | Suppression of tumor growth (apoptosis) | [109] |
| Cecropin | Housefly (M. domestica) | Cecropin | BEL-7402 mouse xenograft | Suppression of tumor growth | [56] |
| Pleurocidin | Atlantic flounder (Pseudopleuronectes americanus) | NRC03,NRC07 | MDA-MB-231 mouse xenograft model | Suppression of tumor growth (necrosis) | [93, 111] |
| β-Sheet and β-hairpin | |||||
| Neutrophil peptide | Human (H. sapiens) | HNP-1, HNP-2, HNP-3 | MOT mouse allograft model | Suppression of tumor growth (of pre-treated cells) | [72] |
| Human (H. sapiens) | HNP-1 | A549 mouse xenograft model (in vivo expression of HNP-1 within A549 cells) | Tumor shrinkage (apoptosis) | [75] | |
| Lactoferricin | Cow (B. taurus) | LfcinB | SH-SY-5Y rat xenograft model | Suppression of tumor growth | [66] |
| Cow (B. taurus) | LfcinB | L5178Y-ML25 xenograft mouse model of liver, spleen and lung metastasis, B16BL6 mouse model of angiogenesis | Inhibition of tumor metastasis, angiogenesis; tumor regression | [65] | |
| Cow (B. taurus) | LfcinB(20–25)4 (tetrameric LfcinB derivative) | Oral squamous cell carcinoma xenograft hamster model | Suppression of tumor growth (necrosis) | [67] | |
| Gomesin | Brazilian spider (A. gomesiana) | Gomesin | B16F10 mouse allograft model, topically treated | Increased lifespan | [69] |
| Tachyplesin | Horseshoe crab (T. tridentatus) | Tachyplesin-RGD | TSU and B16 mouse xenografts | Suppression of tumor growth | [70] |