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Regulation of GLI by ubiquitin ligases and deacetylation. *E3 ligases include BTrCP, Itch, and SPOP. KCTD11, also an E3 ligase is located on chromosome 17p. SPOP is located on chromosome 17q. HDAC-1 is a deacetylase for GLI, which may also play a role in Notch, WNT, and MYC signaling
