Fig. 5.

Chromosome 17 and the ubiquitin-proteasome system in MB. E1-ubiquitin activating enzyme; E2-ubiquitin conjugating enzyme; E3-ubiquitin ligase; Dub-deubiquitinase; Sub-substrate; U-Ubiquitin. Color coding for genes: red ubiquitin conjugase (Ube2G1); green ubiquitin ligase (Rnf167, Kctd11, Fbxo29, Neurl4, Rnf222, Fbxw10, Cdc27, Spop, Rnf43, Trim27, respectively); gold, deubiquitinase (Usp6, Usp39, Usp36, respectively); yellow proteasome subunits (PSMB6, PSMD11, PSMB3, PSMD3, PA28γ, PSMC5, PSMD12, respectively)