Table 3.
Proteasome subunits as signature genes as per the Thompson dataset
| Gene | Location | Subunit | Reference | Group A | Group B (WNT) | Group C | Group D (SHH) | Group E |
|---|---|---|---|---|---|---|---|---|
| PSMA1 | 11p15.2 | α6 | ||||||
| PSMA2 | 7p14.1 | α2 | T | Up | Up | Down* | ||
| PSMA3 | 14q23.1 | α7 | ||||||
| PSMA4 | 15q25.1 | α3 | T | Up | Down* | |||
| PSMA5 | 1p13.3 | α5 | ||||||
| PSMA6 | 14q13.2 | α1 | T | Up* | ||||
| PSMA7 | 20q13.33 | α4 | ||||||
| PSMB1 | 6q27 | β6 | T | Up* | Down | |||
| PSMB2 | 1p34.3 | β4 | T | Up | Down* | Up | ||
| PSMB3 | 17q12 | β3 | ||||||
| PSMB4 | 1q21.3 | β7 | T | Up | Down* | Up | ||
| PSMB5 | 14q11.2 | β5–chy | T | Up | Down* | Up | ||
| PSMB6 | 17p13 | β1–cas | T | Up | Down* | |||
| PSMB7 | 9q33.3 | β2–tryp | ||||||
| PSMB8 | 6p21.3 | β5i | ||||||
| PSMB9 | 6p21.3 | Β6i | ||||||
| PSMC1 | 14q32.11 | Rpt2 | ||||||
| PSMC2 | 7q22.1 | Rpt1 | T | Up | Up* | Down | ||
| PSMC3 | 11p11.2 | Rpt5 | ||||||
| PSMC4 | 19q13.2 | Rpt3 | T | Down* | ||||
| PSMC5 | 17q23.3 | Rpt6 | ||||||
| PSMC6 | 14q22.1 | Rpt4 | ||||||
| PSMD1 | 2q37.1 | Rpn2 | T | Up | Down | Down | ||
| PSMD2 | 3q27.1 | Rpn1 | T | Down* | ||||
| PSMD3 | 17q.21.1 | Rpn3 | ||||||
| PSMD4 | 1q21.3 | Rpn10 | T | Up* | Down | |||
| PSMD5 | 9q33.2 | |||||||
| PSMD6 | 3p14.1 | Rpn7 | T | Up* | Down | Down | ||
| PSMD7 | 16q23–24 | |||||||
| PSMD8 | 19q13.2 | Rpn12 | ||||||
| PSMD9 | 12q24.31–32 | Rpn4 | T | Down* | Up | |||
| PSMD10 | xq22.3 | |||||||
| PSMD11 | 17q11.2 | Rpn6 | T | Up | Down | |||
| PSMD12 | 17q24.2 | Rpn5 | T | Up | Up* | Down | ||
| PSMD13 | 11p15.5 | Rpn9 | ||||||
| PSMD14 | 2q14.2 | Rpn11 | T | Up | Down | |||
| PSME1 | 14q11.2 | T | Down | |||||
| PSME2 | 14q12 | T | Up | Down* | ||||
| PSME3 | 17q21.31 | PA28γ |
T located gene is in the Thompson dataset; Up/down gene expression was reported as significantly increased or decreased relative to that of the other groups
* High level of significance at p < 0.0001