. 2016 Sep 3;74(3):449–467. doi: 10.1007/s00018-016-2354-3

Table 4.

Ubiquitin ligases as marker genes in medulloblastoma

Gene symbol	Gene name	Thompson subgroups^a					Robinson—copy number variation^b
Gene symbol	Gene name	A	B	C	D	E	Robinson—copy number variation^b
Anapc5	Anaphase promoting complex subunit 5			D		D
Anapc13	Anaphase promoting complex subunit 13					D
ARIH1	Protein ariadne-1 homolog	U
ASB13	Ankyrin repeat and SOCS box containing 13		U				Loss
Brap	BRCA1-associated protein				D
Ccnb1ip1	Cyclin B1 interacting protein 1			D	U
Cdc20	Cell division cycle 20			D	U
Cdc27	Cell division cycle 27 (aka Anapc3)			U			Gain
Cul3	Cullin 3			U		D	Gain
Cul4b	Cullin 4b					D	Loss
Cops3	Signalosome subunit 3	U					Gain or Loss
Enc1	Ectodermal-neural cortex 1	U	D				Gain
Fbxo2	F-box protein 2			U
Fbxo9	F-box protein 9	U	D	U
Fbxo26	F-box protein 26		U		U
Fbxo28	F-box protein 28			U	D		Gain
Fbxw1B	F-box and WD repeat domain containing 11			U
Fbxw2	F-box and WD repeat domain containing 2	U					Loss
Fbxw7	F-box and WD repeat domain containing 7			U			Loss
Fbxl7	F-box and leucine-rich repeat protein 7	D	U				Gain
Fbxl14	F-box and leucine-rich repeat protein 14		D		U		Gain
Fem1B	FEM-1-like death receptor binding protein					D	Gain
Herc3	HECT And RLD domain containing			U
Kbtbd2	Kelch repeat and BTB domain containing 2				D		Gain
Kbtbd4	Kelch repeat and BTB domain containing 4					U
Kbtbd9	Kelch repeat and BTB domain containing 9		D
Mid1	Midline 1 (aka Trim18)		U				Loss
Mycbp2	MYC binding protein 2			U			Gain or loss
Neurl	Neuralized E3 ubiquitin-protein ligase 1	D		U
Parc	P53-associated Parkin-like cytoplasmic protein		D
Peli1	Pellino E3 ubiquitin-protein ligase 1		U				Gain
Phip	Pleckstrin homology interacting protein		D				Gain or loss
Pias1	Protein inhibitor of activated STAT 1			U	D		Gain
PPil2	Peptidylprolyl isomerase-like 2			D			Gain
Rabgef1	RAB guanine nucleotide exchange factor 1	U			D		Gain
Ring1	Really interesting new gene 1 protein		D				Gain
RNF5	Ring finger protein 5		D
RNF43	Ring finger protein 43		U				Gain
RNF44	Ring finger protein 44			D
RNF130	Ring finger protein 130			D	U		Gain or loss
RNF146	Ring finger protein 146			U
RNF166	Ring finger protein 167			D
Rnf173	Ring finger protein 173		D	U
Skp1A	S-phase kinase-associated protein 1			U	D		Gain
Skp2	S-phase kinase-associated protein 2			D
Socs2	Suppressor of cytokine signaling 2		U				Gain
Socs5	Suppressor of cytokine signaling 5			U
Socs6	Suppressor of cytokine signaling 6		U				Gain
Traf3	TNF receptor-associated factor 3				D
Trim2	Tripartite motif containing 2					D
Trim26	Tripartite motif containing 26		D				Loss
Trim28	Tripartite motif containing 28			D	U		Gain or loss
Trim37	Tripartite motif containing 37			U			Gain
Trim45	Tripartite motif containing 45	D
TTC3	Tetratricopeptide repeat domain 3			U
Tulp3	Tubby-like protein 3				U		Gain

^aSignificantly up (U) or down (D) in Thompson (Ref 7) subgroups

^bAssociated with copy number gain or loss in Robinson data (Ref 21)