Fig. 5.

Superimposing disorder prediction onto a multiple sequence alignment enables rate inference of disorder and order for homologous sites over a phylogenetic tree based on the corresponding multiple sequence alignment. Conservation of intrinsic disorder versus rate of disorder-order transition for four hypothetical sites: while the first site is conserved in disorder, sites 2–4 have a conservation of 0.5 but the rate varies from slow to fast depending on the pattern of disorder and order in the evolutionary context