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Receiver operating characteristic (ROC) curves comparing the diagnostic accuracy of S100A8 immunohistochemistry (IHC) (blue) to PRAME IHC (red) in distinguishing melanoma and melanoma in situ samples from the case group from the benign common and dysplastic naevi samples from the control group. The combined ROC curve for S100A8 and PRAME IHC is in green. Both curves are compared with the grey curve for chance (under the ROC curve = 0.5). AUC, area under the ROC curve.
