Table 1.
Patient demographics and melanocytic lesion characteristics.1
| Characteristics, n (%) | Common nevus (n=56) | Dysplastic nevus (n=54) | Melanoma in situ (n=58) | Melanoma (n=41) |
|---|---|---|---|---|
| Sex of patient | ||||
| Male | 23 (41.1) | 28 (51.9) | 33 (56.9) | 27 (65.9) |
| Female | 33 (58.9) | 26 (48.1) | 25(43.1) | 14 (34.1) |
| Age of patient | ||||
| < 35 yrs old | 19 (33.9) | 7 (13.0) | 1 (1.7) | 4 (9.8) |
| 35–70 yrs old | 35 (62.5) | 40 (74.1) | 40 (69.0) | 20 (48.8) |
| >70 yrs old | 2 (3.6) | 7 (13.0) | 17 (29.3) | 17 (35.4) |
| Location of tumor | ||||
| Face | 5 (8.9) | 1 (1.9) | 10 (17.2) | 7 (17.1) |
| Scalp, Neck | 9 (16.1) | 0 (0.0) | 5 (8.6) | 5 (9.8) |
| Trunk | 29 (51.8) | 41 (75.9) | 19 (32.8) | 10 (24.4) |
| Upper extremities | 5 (8.9) | 7 (13.0) | 20 (34.5) | 10 (24.4) |
| Lower extremities | 8 (14.3) | 5 (9.3) | 4 (6.9) | 7 (17.1) |
| Histologic growth pattern | ||||
| Junctional | 7 (12.5) | 26 (48.1) | N/A | N/A |
| Compound | 24 (42.9) | 28 (51.9) | N/A | N/A |
| Intradermal | 25 (44.6) | 0 (0.0) | N/A | N/A |
| Tumor thickness, avg. (range) | N/A | N/A | N/A | 2.31 (0.2–50) |
| Ulcerations | ||||
| Present | N/A | N/A | N/A | 4 (9.8) |
| Absent | N/A | N/A | N/A | 29 (70.7) |
| Indeterminate | N/A | N/A | N/A | 8 (19.5) |
| Primary tumor stage | ||||
| T1a | N/A | N/A | N/A | 23 (56.1) |
| T1b | N/A | N/A | N/A | 1 (2.4) |
| T1 indeterminate2 | N/A | N/A | N/A | 5 (12.2) |
| T2a | N/A | N/A | N/A | 1 (2.4) |
| T2b | N/A | N/A | N/A | 1 (2.4) |
| T2 indeterminate | N/A | N/A | N/A | 0 (0.0) |
| T3a | N/A | N/A | N/A | 4 (9.8) |
| T3b | N/A | N/A | N/A | 1 (2.4) |
| T3 indeterminate | N/A | N/A | N/A | 2 (4.9) |
| T4a | N/A | N/A | N/A | 1 (2.4) |
| T4b | N/A | N/A | N/A | 1 (2.4) |
| T4 indeterminate | N/A | N/A | N/A | 1 (2.4) |
| Melanoma subtype | ||||
| Superficial spreading | N/A | N/A | N/A | 1 (2.4) |
| Nodular | N/A | N/A | N/A | 1 (2.4) |
| Lentigo maligna3 | N/A | N/A | N/A | 1 (2.4) |
| Acral lentiginous | N/A | N/A | N/A | 0 (0.0) |
| Indeterminate | N/A | N/A | N/A | 36 (87.8) |
| Other | N/A | N/A | N/A | 3 (7.3) |
1
S100A8 staining reported in: Kiuru M, Kriner MA, Wong S, et al. High-Plex Spatial RNA Profiling Reveals Cell Type–Specific Biomarker Expression during Melanoma Development. J Invest Dermatol. May 2022;142(5):1401–1412.e20. doi:10.1016/j.jid.2021.06.041
2
Cases were indeterminate if the presence of ulceration was unknown.
3
There was one melanoma classified as being both superficial spreading type and lentigo maligna.