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. 2024 May 17;14:33–46. doi: 10.2147/DNND.S445130

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© 2024 Singh et al.

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Sequential progression of prostate cancer pathogenesis and the intersection of ADT in the pathology.

Abbreviations: S5A1, steroid 5 alpha-reductase 1; S5A2, steroid 5 alpha-reductase 2; HSP, heat shock protein; PSA, prostate-specific antigen; nPEc, normal prostate epithelial cell; PIN, prostate intraepithelial neoplasia; LGc, low grade carcinoma; HGc, high grade carcinoma; ADT, androgen deprived therapy; GnRH, gonadotropin-releasing hormone agonist; Nkx3.1, NK3 homeobox 1; GSTP, glutathione S-transferase Pi; KLF6, kruppel-like factor 6; PTEN, phosphatase and TENsin homolog; EPHB2, EPH receptor B; E-cad, e-cadherin; α-cad, alpha-cadherin; pRb, retinoblastoma protein; Kal1, Kallmann syndrome 1 sequence 1; CD44, cell surface adhesion receptor 44.