Fig 2. edNEG modeling of physiological and pathological activity.
Model’s response to different stimulus strenghts, illustrated by three representative state variables: membrane potential of neuronal soma (ϕmsn), potassium concentration in extracellular space outside soma ([K+]se), and deviance from baseline values of the extracellular space volume outside soma (ΔVse). (A,C,E) Physiological response to a 8 × 10−5 μA stimulus current applied to the somatic compartment between t = 0.2 s and t = 5.5 s. (B,D,F) Pathological response to a 20 × 10−5μA stimulus current applied to the somatic compartment between t = 0.2 s and t = 5.5 s. The edNEG model was originally presented in Sætra et al. 2021 [20].