Table 3. Crude and an adjusted Hazard Ratios (HR) for association between long-term survival of CM patients and exposures at Cox proportional hazard regression.
| Crude Hazard Ratios | Adjusted Hazard Ratios | ||||||
|---|---|---|---|---|---|---|---|
| Variable | CM Total (Deaths) | HR | 95% CI | P-value | HRv | 95% CI | P-value |
| Primary Exposure | |||||||
| Overall Group w | |||||||
| CM-DTP | 199 (148) | 0.36 | (0.26, 0.48) | <0.001 | 0.35 | (0.24, 0.49) | <0.001 |
| Secondary Exposures | |||||||
| Fluconazole Adherence x | |||||||
| Not Used | 139 (139) | 1.00 | 1.00 | ||||
| Adhered | 52 (10) | 0.02 | (0.01, 0.04) | <0.001 | 0.02 | (0.01, 0.04) | <0.001 |
| Defaulted | 52 (42) | 0.13 | (0.09, 0.20) | <0.001 | 0.13 | (0.08, 0.20) | <0.001 |
| ART Status y | |||||||
| Naïve | 17 (17) | 1.00 | 1.00 | ||||
| Adhered | 174 (137) | 0.35 | (0.21, 0.59) | <0.001 | 0.59 | (0.34, 1.01) | 0.054 |
| Defaulted | 10 (6) | 0.25 | (0.10, 0.64) | 0.004 | 0.59 | (0.22, 1.58) | 0.291 |
| Restarted | 21 (17) | 0.27 | (0.14, 0.54) | <0.001 | 0.50 | (0.25, 1.03) | 0.061 |
| Follow-up Adherence z | |||||||
| No follow-up returns | 146 (146) | 1.00 | 1.00 | ||||
| Adhered | 53 (13) | 0.02 | (0.01, 0.04) | <0.001 | 0.02 | (0.01, 0.05) | <0.001 |
| Defaulted | 62 (50) | 0.12 | (0.08, 0.17) | <0.001 | 0.12 | (0.08, 0.18) | <0.001 |
v Adjusted Hazard Ratio (HR), Confidence Interval (CI); Lumbar puncture (LP); P value level of significance <0.05 (indicating significant p values.
w Treatment Group adjusted for Age, Sex, and Antiretroviral use status
x Fluconazole adherence adjusted for Age, Sex, and Treatment Group
y Antiretroviral use status adjusted for Age, Sex, and Treatment Group
z Follow-up adherence adjusted for Age, Sex, and Treatment Group