Fig. 10.

Inhibition of ΔF508-CFTR currents by Naltriben. a I–V normalized curves for CFTR currents in cells expressing ΔF508-CFTR (whole-cell configuration with 5 mM Mg-ATP in the intracellular buffer) in the presence or absence of Naltriben. CFTR was activated by FSK and GST and inhibited by CFTR inhibitor 172, indicating that the recorded currents were due to CFTR. The inhibition by Naltriben is more efficient than that of inhibitor 172. b Bar chart showing the statistical analysis of currents (+80 mV) indicating that ΔF508-CFTR function is decreased by Naltriben