Fig. 11.

Activation of G551D-CFTR currents by Naltriben. a I–V normalized curves for CFTR currents in cells expressing G551D-CFTR (with 5 mM Mg-ATP in the intracellular buffer) plus Naltriben. CFTR was activated by FSK and GST, and inhibited by CFTR inhibitor 172, indicating that the recorded currents were due to CFTR. The activation by Naltriben is more efficient than that of FSK plus GST. b Bar chart showing the statistical analysis of currents (+80 mV) indicating that G551D-CFTR function is very significantly increased by Naltriben