Fig. 9.

Inhibition of WT-CFTR currents by Naltriben. a I–V curves (normalized by cell capacitance pF, mean ± SEM) for CFTR currents in WT-CFTR expressing cells, with 5 mM Mg-ATP in the intracellular buffer. CFTR was activated by FSK and GST, and inhibited by CFTR inhibitor 172, indicating that the recorded currents were due to CFTR. b Curves obtained in the presence of Naltriben and Carvacrol were plotted. Naltriben and Carvacrol activates and inhibites CFTR, respectively. c Bar chart showing the statistical analysis of the currents noted at +80 mV indicating that WT-CFTR function is decreased in the presence of Naltriben