Table 1.
Summary of SVs described in hESC lines during prolonged in vitro culture
| Structural variations | Aberration | Putative candidates | References | |
|---|---|---|---|---|
| Genes | miRNA | |||
|
1q11–1p36 1q31.3 |
Gain | MCL1, IL6R, PSMD4, PSMB4, UBE2Q, UBAP2L, RBM8A, RPS27, PIAS3, POLR3C, HIST2H2AA, LASS2, MRPL9, JTB, HAX1, SHC1, APH-1A, BCL9, ZNF364, SSR2, MAPBPIP, CCT3, MEF2D, C1orf85 | hsa-mir-9-1 | [22, 66, 182] |
| Partial chromosome 12 or isochromosome 12p | Gain | NANOG, DPPA3 (Stella-Related), GDF3, CCND2 | n.d. | [17, 22, 183] |
|
17q11–q12, 17q21–17q23.2, 17q25–qter |
Gain | BIRC5 | miRNA has-mir-21 | [17, 22] |
| 20q11.21 | Gain | DNMT3B, TPX2, KIF3B, BCL2L1 PDRG1 | n.d. | [22, 66–68] |
| 8q24.3 | Loss | n.d. | n.d. | [18, 21, 46, 53, 184] |
| 10p13pter | Loss | n.d. | n.d. | |
| 16q | Loss | n.d. | n.d. | |
| 18q21qter | Loss | n.d. | n.d. | |
| 22q13qter | Loss | n.d. | n.d. | |
n.d. not detected