Table 1.

Core components and regulators of the EGFR signalling pathway in the Drosophila eye

Fly gene Name	Symbol	Also known as	Cellular location	Function	Reference
Core components
Epidermal growth factor receptor	Egfr	DER, torpedo, fib	Plasma membrane	RTK	[1]
spitz	spi		Secreted	Ligand	[8]
Keren	Krn		Secreted	Ligand	[9]
downstream of receptor kinase	drk	GRB2	Cytoplasm	Adaptor protein	[12]
SHC adaptor protein	Shc		Cytoplasm	Adaptor protein	[13]
Son of sevenless	Sos		Cytoplasm	GEF	[14]
Ras oncogene at 85D	Ras85D	Ras, Ras1	Cytoplasm	small GTPase	[15]
Raf oncogene	Raf	pole hole	Cytoplasm	Protein kinase	[18]
Downstream of raf1	Dsor1	MAPKK, MEK	Cytoplasm	Protein kinase	[19]
rolled	rl	MAPK, ERK	Cytoplasm	Conventional MAPK	[20]
pointed	pnt		Nucleus	ETS transcriptional activator	[21]
Positive regulators
rhomboid	rho	Rho-1	Golgi/endosome	Protease for Spitz cleavage	[42, 44]
roughoid	ru	Rho-3	Golgi/endosome/ER	Protease for Spitz cleavage	[50]
Star	S		ER/Golgi	Chaperone	[46]
rasp	rasp	skl, sit	Golgi	Palmitoyltransferase	[43]
kinase suppressor of Ras	ksr	KSR-1	Cytoplasm	Scaffolding protein, protein kinase	[58]
connector enhancer of ksr	enk		Cytoplasm	Raf activator/inhibitor	[61]
aveugle	ave	HYP	Cytoplasm	Raf activator	[63, 64]
steppke	step	Grp1	Cytoplasm	Arf GEF	[66]
corkscrew	csw	SHP2	Cytoplasm	Tyrosine phosphatase	[68]
mago nashi	mago		Nucleus	MAPK premRNA splicing	[57]
myopic	mop		Endosome	Endocytic pathway	[38]
Hepatocyte growth factor regulated tyrosine kinase substrate	Hrs	vps27	Endosome	Endocytic pathway	[38]
Vacuolar protein sorting 4	Vps4	SKD1	MVB (cytoplasm ?)	unclear	[33]
nejire	nej	CBP/p300	Nucleus	Acetyl transferase	[101]
Negative regulators
Argos	Aos		secreted	Ligand inhibitor	[70]
kekkon-1	kek1		Transmembrane	Egfr binding	[76]
Neuroglian	Nrg		Transmembrane	Ed binding	[79]
echinoid	ed		Transmembrane	Egfr binding	[78]
Fasciclin2	Fas2		Transmembrane	unclear	[80]
sprouty	sty	Spry	Cytoplasm	Protein interaction, endocytosis	[81, 82]
Ras GTPase activating protein 1	Gap1	gap1, rasGAP	Cytoplasm	Negative regulator of Ras85D	[83]
Rho GTPase activating protein at 5A	RhoGAP5A		Cytoplasm	Rho GTPase activator	[85]
vav ortholog (H. sapiens)	vav		Cytoplasm	Rho GTPase GEF	[88]
Cbl proto-oncogene ortholog	Cbl		Cytoplasm	Endocytosis	[34]
shibire	shi	dynamin	Cytoplasm	Endocytosis	[31]
small wing	sl	PLCc	Cytoplasm	cSpitz retention in ER	[54]
rhomboid-5	rho-5	iRhom		Spitz degradation through ERAD	[45]
klumpfuss	klu		Nucleus	Transcription factor	[93]
Hairless	H		Nucleus	Transcriptional repressor	[95]
capicua	cic		Nucleus	Transcriptional repressor	[99]
anterior open	aop	Yan	Nucleus	ETS transcriptional repressor	[97]