Fig. 2.

Proteins involved in the mediation of the crosstalk between the UPS and autophagy in Alzheimer’s disease. They are classified based on their ability to interact with Ub and LC3. BUZ, Ub-binding zinc-finger domain; PB1, Phox and Bem1p domain; ZZ, Zinc-finger domain; TB, TRAF6 binding domain; LIR, LC3-interacting domain; KIR, Keap1-interacting region; UBA, Ub-associated domain; CC, coiled-coil domain; SKICH, SKIP–carboxyl homology domain; Gal-8, Galectin-8 binding domain; UBZ, Ub-binding zinc-finger domain; NLS, nuclear localization signal; BAG, Bcl-2-associated athanogene 1 domain; BEACH, BEACH domain; WD40, WD40 repeats; FYVE, Fab1,YOTB/ZK632.12, Vac1, and EEA1 domain; WW, WW domain