Fig. 1.

Skin is comprised of the outer epidermis, the dermis, and the hypodermis. The epidermis is made up of four distinct layers, such as stratum basale (SB), stratum spinosum (SS), stratum granulosum (SG), and the stratum corneum (SC), representing keratinocytes at different stages of differentiation. Members of the adopted and orphan nuclear receptors are involved in critical processes, such as wound repair, permeability barrier homeostasis, and repair of UV damage. A number of receptors may be targeted to address skin inflammation that underpins a number of acute and chronic skin disorders