Table 1.
Neurotransmitters, neuropeptides and peptide hormones acting on IPCs in Drosophila melanogaster
| Substance | Production sitea | Receptor on IPCs | Stage | References |
|---|---|---|---|---|
| GABA | Brain neurons | GABAB | Adult | [86, 87] |
| Serotonin | Brain neurons | 5-HT1A | Adult | [108] |
| Octopamine | Brain neurons | OAMB | Adult | [57] |
| sNPF | Brain neuronsb | sNPFR1 | Adult | [91] |
| Corazonin | Brain neuronsb | CrzR (GRHRII)c | Adult | [91] |
| Tachykinin | Brain neurons, ECd | DTKR (TkR99D) | Adult | [94] |
| Allatostatin A | Brain neurons, ECd | DAR2 (AstA-R2) | Adult | [96] |
| CCHamide2 | EC (fat body?) | CCHa2-R | Adulte/larva | [100, 101] |
| Limostatin | Corpora cardiacaf | LstR (PK1-R)g | Adult | [103] |
| DILP6 | Fat body | dInR (InR) | Adult | [90] |
| Adiponectin | Fat body | AdipoR | Adult/larva | [89] |
| AKH | Corpora cardiaca | AkhR (GRHR) | Adult/larva | [77, 96] |
aIn most cases, tentative site of production is shown and actual cells releasing onto IPCs have rarely been identified
bThe DLP neurons of pars lateralis
cIn brackets synonyms are given
d EC enteroendocrine cells. Like suggested for CCHamide2 [100], these peptides may enter the circulation and act on IPCs
eThe adult action on IPCs is less well documented
fMore specifically, the endocrine cells that also produce AKH
gAlso known as PK1-R, a pyrokinin 1 receptor (CG9918, a neuromedin U-receptor-like GPCR)