Fig. 2.

Apical restriction of Par3/Baz localization by inhibitory kinases. Structures of epithelial cells in Drosophila (left) and in mammals (right), with the different protein orthologues implicated in Par3/Baz restriction, are presented. AJs, (shown in red) are localized apically at the interface between the apical and basal membranous domains characterized by antagonizing protein complexes: the apical Par6/PKCζ (green), and the baso-lateral Dlg/Lgl/Scrib/Par1 (blue). Par3 accumulates at the level of AJs due to a double restriction by the apical kinase PKCζ and by the basal kinase Par1. The domains of these two kinases stay segregated due to the mutual exclusion of the apical (green) and baso-lateral (blue) protein complex networks. Par3 levels are further modulated along the circumference of the AJ domain by the antagonizing Rho-Kinase (ROCK)