Fig. 6.

Generation of F1s carrying large deletions of TYR. a Sequence analysis of rabbit containing a large deletion of TYR (#106) and New Zealand white rabbit. SNP is indicated by the blue arrows. Deletions (−) and insertions (+) are shown. WT wild-type allele, NW New Zealand white rabbit. b Picture of the F1 TYR mutant rabbit; four of the F1 rabbits exhibited the typical albinism phenotype; others are wild-type rabbits. c Determination of large deletions of TYR in F1 rabbits by PCR. A clear band demonstrates a large-fragment deletion of TYR is present in #401, #402, #403, and #404. Primers 1F and 1R were used for mutant determination. M DNA ladder. d T-cloning sequence analysis of the F1 rabbits. SNP is indicated by the blue arrows. Deletions (−) and insertions (+) are shown. WT wild-type allele