Extended Data Fig. 5. Association of molecular alterations with immune phenotypes.

Extended Data Fig. 5 Association of molecular alterations with immune phenotypes. Presence or absence of the individual mutations known to be associated with immune resistance in other cancers was compared to the immune phenotypes associated with clinical benefit in the current study. a. Association between the individual mutations and CD8+PD-1+TOX+ T cells. b. Association between the individual mutations and interaction between CD8+PD-1+ T cells and PD- L1+ cells. (a,b): N = 24. Statistical comparisons were performed using Mann-Whitney test. Measure of centre represents the median with error bars representing 95% CI. Two-sided P value by Mann-Whitney test without multiple comparison adjustment is shown. c. Association between tumor mutational burden and immune phenotypes. Pearson correlation coefficients with two-sided P values are shown (N = 24).