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. 2024 Apr 25;4(5):625–637. doi: 10.1038/s43587-024-00626-y

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 2 — a) Left hippocampus ROI (n = 77 independent individuals); b) Right hippocampus ROI (n = 77 independent individuals); c) Bilateral hippocampus (averaged left and right hippocampus ROIs) (n = 77 independent individuals). The scatter plots reflect the association between baseline LC intensity_r and tau accumulation in hippocampus at follow-up (robust linear regression, p < 0.05 two-tailed analysis, uncorrected for multiple comparisons). Plots are adjusted for age, sex, CDR and neocortical PiB burden. In all plots, dots represent the individual predicted values of the relationships tested and the shaded areas around the fit lines show 95% CI. Abbreviations: FTP = 18-flortaucipir PET; HIP=hippocampus; p = p value; PVC=partial volume corrected; SUVR=standardized uptake value ratio.

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