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. 2024 Apr 25;4(5):625–637. doi: 10.1038/s43587-024-00626-y

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 4 — (a) Baseline LC integrity (inverted signal) was used as a predictor of longitudinal tau accumulation at the whole-brain voxel-wise GLM level controlling for sex and age or sex, age, CDR (n = 77 independent individuals). The associations between LC integrity and medial temporal lobe regions (for example, hippocampus) were smaller in cluster size but remained significant. (b) The choroid plexus FTP-signal was residualized from tau-PET images and added to our associations between LC integrity and cortical tau; then, the additional covariates (sex, age, CDR) were added (whole-brain voxel-wise level GLM analysis) (n = 77 independent individuals). Although the cluster extension was reduced, the associations remained significant. Results are p value < 0.05 cluster-corrected. The brain projection shows one-tailed results (z-score > 1.64; the color bar shows the z-statistics; cooler colors represent a stronger association). In (A) and (B), The results are displayed on sagittal, coronal and axial brain views using FSLeyes (FSL, FMRIB, Oxford, UK). Abbreviations: CDR=Clinical Dementia Rating; RH=Right hemisphere.