Extended Data Fig. 5. Associations between LC integrity and cortical tau accumulation moderated by neocortical PiB burden after controlling for the effect of covariates of no interest.

(a) The interaction between baseline LC integrity (inverted signal) and neocortical PiB burden (Aβ) as predictor of longitudinal tau accumulation at the whole-brain voxel-wise level GLM analysis controlling for sex and age or sex, age, and CDR (n = 75 independent individuals). The associations between LC integrity and medial temporal lobe regions (for example, hippocampus) and posterior occipital regions were similar when controlling for age and sex and were smaller in cluster size when controlling for CDR but remained significant. (b) The choroid plexus FTP-signal was residualized from tau-PET images and added to our associations between Aβ and LC integrity predicting cortical tau; then, the additional covariates (age, sex, and CDR) were added (whole-brain voxel-wise level GLM analysis) (n = 75 independent individuals). Although the cluster extension was reduced, the associations remained significant. Results are p value < 0.05 cluster-corrected). The brain projection shows one-tailed results (z-score > 1.64; the color bar shows the z-statistics; cooler colors represent a stronger association). In (A) and (B), the results are displayed on sagittal, coronal and axial brain views using FSLeyes (FSL, FMRIB, Oxford, UK). Abbreviations: CDR=Clinical Dementia Rating; RH=Right hemisphere.