Figure 2.

(A) Microenvironment cell population (MCP) scores of the individual immune cell types according to DDIR status. (B) Increased immune infiltrates correlated highly with DDIR positivity. MCP scores of three immune infiltrates—T-cells (blue), B lineage (red), and monocytic lineage (green)—correlated with DDIR scores with a line of best fit for each immune infiltrate. The black dashed horizontal line denotes the DDIR positivity cut-off. (C) Cytotoxic lymphocyte MCP scores correlated with DDIR scores in the GO2 population. The black horizontal line denotes the cut-off for DDIR positivity. Boxplot denotes the distribution of values for DDIR-positive and -negative status in the cohort.

DDIR, DNA damage immune response; NEG, DDIR-negative; NK, natural killer; POS, DDIR-positive.