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. 2024 May 21;14:11570. doi: 10.1038/s41598-024-62470-9

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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DW-MRI (b = 0 s/mm²), DCE-MRI images (2nd time point after AIF peak), and parameter maps per visit of a metastatic colorectal cancer tumor located in the liver of patient 102–003-105 (tumor 2). Contour annotation of tumor is shown as dashed red line. After PEGPH20 (Day 1) a decrease in ADC and T1, and an increase in iAUC, k^trans, and v_e, within the tumor are observed. An increase in v_p is observed in few pixels.