Table 2.
GWAS lead SNPs
| Trait | CHR | BP | dbSNP | Effect Allele | Other Allele | EAF | BETA | SE | P | Nearest gene |
|---|---|---|---|---|---|---|---|---|---|---|
| LAmax | 6 | 31294375 | rs9265346 | G | A | 0.33 | 0.045 | 0.007 | 1.10E-09 | HLA-B |
| LAmax | 6 | 79554193 | rs6926537 | T | A | 0.512 | −0.039 | 0.007 | 9.10E-09 | IRAK1BP1 |
| LAmax | 6 | 107433645 | rs60237682 | T | C | 0.683 | −0.041 | 0.007 | 3.80E-08 | BEND3 |
| LAmax | 12 | 66343400 | rs1038196 | G | C | 0.486 | 0.039 | 0.007 | 1.10E-08 | HMGA2 |
| LAmax | 19 | 46213416 | rs62111731 | A | G | 0.479 | 0.042 | 0.007 | 7.10E-10 | FBXO46 |
| LAmax indexed | 2 | 179650954 | rs6715901 | G | A | 0.507 | −0.043 | 0.008 | 1.20E-08 | TTN |
| LAmax indexed | 4 | 111665783 | rs2634073 | T | C | 0.166 | 0.057 | 0.01 | 2.00E-08 | PITX2 |
| LAmax indexed | 5 | 32831670 | rs13154066 | T | C | 0.402 | −0.05 | 0.008 | 6.60E-11 | NPR3 |
| LAmax indexed | 6 | 31229203 | rs9264391 | G | A | 0.893 | −0.089 | 0.014 | 9.30E-11 | HLA-C |
| LAmax indexed | 6 | 107442277 | rs9480737 | A | G | 0.682 | −0.05 | 0.008 | 8.80E-10 | BEND3 |
| LAmax indexed | 19 | 46166806 | rs140153691 | T | TGC | 0.639 | −0.047 | 0.008 | 4.10E-09 | GIPR |
| LAmax indexed | 22 | 26156505 | rs133873 | T | A | 0.775 | −0.055 | 0.009 | 9.60E-10 | MYO18B |
| LAEF | 1 | 51322205 | rs79948214 | A | G | 0.984 | 0.161 | 0.029 | 4.70E-08 | FAF1 |
| LAEF | 1 | 116310967 | rs4074536 | T | C | 0.702 | −0.052 | 0.008 | 7.80E-11 | CASQ2 |
| LAEF | 14 | 23874117 | rs440466 | T | C | 0.622 | 0.056 | 0.008 | 7.30E-14 | MYH6 |
| LAEF | 22 | 26159289 | rs133885 | G | A | 0.548 | 0.046 | 0.007 | 3.60E-10 | MYO18B |
| LAmin | 6 | 31294375 | rs9265346 | G | A | 0.33 | 0.044 | 0.007 | 8.30E-09 | HLA-B |
| LAmin | 6 | 79518638 | rs35790661 | C | CCA | 0.63 | −0.043 | 0.007 | 4.40E-09 | IRAK1BP1 |
| LAmin | 6 | 107442277 | rs9480737 | A | G | 0.682 | −0.041 | 0.007 | 3.10E-08 | BEND3 |
| LAmin | 10 | 92681480 | rs780162510 | CATA | C | 0.49 | 0.04 | 0.007 | 2.20E-08 | ANKRD1 |
| LAmin | 11 | 65336819 | rs3782089 | C | T | 0.928 | 0.074 | 0.013 | 4.70E-08 | SSSCA1 |
| LAmin | 15 | 99248018 | rs4966014 | C | T | 0.3 | 0.045 | 0.008 | 4.20E-09 | IGF1R |
| LAmin | 19 | 46315357 | AT | A | 0.476 | 0.047 | 0.007 | 1.20E-11 | RSPH6A | |
| LAmin | 22 | 26164079 | rs133902 | C | T | 0.56 | −0.041 | 0.007 | 4.30E-09 | MYO18B |
| LAmin indexed | 2 | 3912741 | rs56289263 | C | T | 0.938 | −0.093 | 0.017 | 4.40E-08 | DCDC2C |
| LAmin indexed | 2 | 179650954 | rs6715901 | G | A | 0.507 | −0.041 | 0.007 | 4.50E-08 | TTN |
| LAmin indexed | 4 | 24289655 | rs1533093 | C | T | 0.862 | −0.062 | 0.011 | 3.80E-08 | DHX15 |
| LAmin indexed | 4 | 111665783 | rs2634073 | T | C | 0.166 | 0.057 | 0.01 | 1.20E-08 | PITX2 |
| LAmin indexed | 5 | 32831670 | rs13154066 | T | C | 0.402 | −0.043 | 0.008 | 1.40E-08 | NPR3 |
| LAmin indexed | 6 | 31294375 | rs9265346 | G | A | 0.33 | 0.047 | 0.008 | 1.00E-08 | HLA-B |
| LAmin indexed | 6 | 107442277 | rs9480737 | A | G | 0.682 | −0.049 | 0.008 | 1.00E-09 | BEND3 |
| LAmin indexed | 8 | 97223162 | rs35216833 | C | T | 0.456 | 0.042 | 0.007 | 1.00E-08 | UQCRB |
| LAmin indexed | 10 | 92586289 | rs112343361 | A | ACT | 0.497 | −0.046 | 0.008 | 1.80E-09 | HTR7 |
| LAmin indexed | 15 | 99248018 | rs4966014 | C | T | 0.3 | 0.047 | 0.008 | 1.80E-08 | IGF1R |
| LAmin indexed | 17 | 45097337 | rs8078336 | G | T | 0.965 | −0.137 | 0.025 | 2.70E-08 | GOSR2 |
| LAmin indexed | 19 | 46292259 | rs7246377 | G | A | 0.534 | −0.049 | 0.007 | 2.80E-11 | DMWD |
| LAmin indexed | 22 | 26156512 | rs133874 | A | G | 0.773 | −0.061 | 0.009 | 6.80E-12 | MYO18B |
| LASV | 6 | 31225196 | rs199610865 | T | TA | 0.853 | −0.055 | 0.01 | 2.90E-08 | HLA-C |
| LASV | 14 | 23869029 | rs376439 | A | G | 0.606 | 0.045 | 0.007 | 2.70E-10 | MYH6 |
| LASV indexed | 6 | 31225196 | rs199610865 | T | TA | 0.853 | −0.067 | 0.011 | 4.70E-10 | HLA-C |
| LASV indexed | 9 | 136138765 | rs8176685 | GCGCCCACCACTA | G | 0.82 | −0.059 | 0.01 | 3.20E-09 | OBP2B |
| LASV indexed | 14 | 23869029 | rs376439 | A | G | 0.606 | 0.048 | 0.008 | 8.10E-10 | MYH6 |
BP GRCh37-base position, dbSNP dbSNP identifier, where available, EAF Effect allele frequency, BETA BOLT-LMM effect size of the effect allele, in units of the rank-based inverse normal transform which approximates a standard deviation change. SE standard error. P two-tailed BOLT-LMM P value. “Indexed” indicates that the trait has been divided by body surface area. Gene names are italicized.