Figure 2.

Lung permeability in mice following sublethal ricin intoxication. Mice were exposed to ricin intoxication (1.7 µg/kg body weight) by intranasal instillation. At different time points post exposure animals were sacrificed and their lungs were collected for analysis. (A) Lung morphology in control (sham) mice or intoxicated mice on day 6 or 30 post exposure. (B) Lung EBD analysis following ricin intoxication. Mice were intravenously injected with 50 mg/kg EBD at the indicated time points and lungs were harvested 1 h later for determination of EBD content. (C) Lung wet/dry weight ratio analysis following ricin intoxication. (D) Wet lung/body weight ratio analysis following ricin intoxication. In all figures each dot represents one animal and data are means ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001 in comparison to non-intoxicated mice.