Table 1.
Clinical, anthropometric, and laboratory characteristics
| T2D | NGT | |||
|---|---|---|---|---|
| DAPA (n = 13) | Placebo (n = 7) | DAPA (n = 8) | Placebo (n = 4) | |
| Sex | Male | Male | Male | Male |
| Age (years) | 57 ± 3.0 | 58 ± 1.7 | 44 ± 2.2 | 47 ± 4.9 |
| BMI (kg/m2) | 30 ± 1.5 | 30 ± 1.9 | 32 ± 1.8 | 31 ± 3.2 |
| FPG (mg/dL) | 155 ± 6 | 121 ± 6* | 109 ± 4 | 98 ± 2* |
| HbA1c (%) | 6.5 ± 0.2 | 6.6 ± 0.2 | 5.2 ± 0.1 | 5.6 ± 0.1 |
| Systolic blood pressure (mmHg) | 125 ± 6 | 127 ± 4 | 123 ± 4 | 121 ± 11 |
| Diastolic blood pressure (mmHg) | 68 ± 3 | 72 ± 4 | 77 ± 6 | 75 ± 8 |
| eGFR (mL/min ⋅ 1.73 m2) | 113 ± 8.9 | 109 ± 9 | 117 ± 10 | 123 ± 22 |
| Hematocrit (%) | 43 ± 1.8 | 41 ± 1.5 | 43 ± 1.3 | 43 ± 0.4 |
| Urine albumin-to-creatinine ratio (μg/mg) | 15 ± 7 | 8 ± 5 | 1 ± 0.1 | 1 ± 0.1 |
| Triglycerides (mg/dL) | 152 ± 24 | 104 ± 12 | 116 ± 15 | 155 ± 31 |
| Total cholesterol (mg/dL) | 178 ± 22 | 142 ± 13 | 180 ± 13 | 198 ± 20 |
| HDL cholesterol (mg/dL) | 36 ± 3 | 43 ± 4 | 38 ± 2 | 45 ± 6 |
| LDL cholesterol (mg/dL) | 112 ± 15 | 78 ± 11 | 119 ± 13 | 121 ± 19 |
Data are presented as the mean ± SEM. eGFR, estimated glomerular filtration rate.
*
P < 0.05 for DAPA vs. placebo.