Table 2.
Relationships of RARa measures with risk of developing dementia or MCIb,c.
| RAR characteristics | Adjusted hazard ratio (95% CI) | |
| Relative amplitude | ||
|
|
Q1d | 1.88 (1.46-2.41) |
|
|
Q2 | 1.29 (0.99-1.67) |
|
|
Q3 | 0.94 (0.71-1.26) |
|
|
Q4 | Reference |
|
|
Per 1-SD decrease | 1.23 (1.16-1.29) |
| M10e | ||
|
|
Q1 | 1.69 (1.30-2.19) |
|
|
Q2 | 1.11 (0.83-1.47) |
|
|
Q3 | 1.03 (0.76-1.38) |
|
|
Q4 | Reference |
|
|
Per 1-SD decrease | 1.28 (1.14-1.44) |
| M10 midpoint | ||
|
|
Earlier | 1.10 (0.90-1.34) |
|
|
Middle | Ref |
|
|
Later | 1.03 (0.83-1.27) |
|
|
Per 1-SD increase | 0.93 (0.84-1.03) |
| L5f | ||
|
|
Q1 | Reference |
|
|
Q2 | 1.23 (0.96-1.57) |
|
|
Q3 | 1.00 (0.78-1.30) |
|
|
Q4 | 1.51 (1.19-1.91) |
|
|
Per 1-SD increase | 1.15 (1.10-1.21) |
| L5 midpoint | ||
|
|
Earlier | 1.06 (0.87-1.30) |
|
|
Middle | Reference |
|
|
Later | 0.86 (0.70-1.06) |
|
|
Per 1-SD increase | 0.92 (0.85-0.99) |
| IVg | ||
|
|
Q1 | Reference |
|
|
Q2 | 1.64 (1.27-2.12) |
|
|
Q3 | 1.37 (1.05-1.78) |
|
|
Q4 | 1.56 (1.20-2.02) |
|
|
Per 1-SD increase | 1.14 (1.05-1.24) |
| ISh | ||
|
|
Q1 | 1.00 (0.78-1.27) |
|
|
Q2 | 0.82 (0.64-1.05) |
|
|
Q3 | 1.01 (0.81-1.26) |
|
|
Q4 | Reference |
|
|
Per 1-SD decrease | 0.98 (0.89-1.07) |
| Amplitude | ||
|
|
Q1 | 1.86 (1.42-2.42) |
|
|
Q2 | 1.28 (0.96-1.70) |
|
|
Q3 | 1.22 (0.91-1.63) |
|
|
Q4 | Reference |
|
|
Per 1-SD decrease | 1.32 (1.17-1.49) |
| Acrophase | ||
|
|
Earlier | 0.99 (0.81-1.20) |
|
|
Middle | Reference |
|
|
Later | 0.90 (0.73-1.13) |
|
|
Per 1-SD increase | 0.93 (0.85-1.02) |
aRAR: rest-activity rhythm.
bMCI: mild cognitive impairment.
cModels are adjusted for age at the time of actigraphy, sex, education, Townsend deprivation index, ethnic background, obesity, sleep apnea, morbidity burdens, circulatory disorders, night shiftwork status, alcohol intake, smoking status, and polygenic risk score of Alzheimer disease.
dQ: quartile.
eM10: activity level of the most active 10-hour period.
fL5: activity level of the least active 5-hour period.
gIV: intradaily variability.
hIS: interdaily stability.