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. 2024 May 11;10(10):e31106. doi: 10.1016/j.heliyon.2024.e31106

Fig. 5.

Fig. 5

The impact of PAC on the RCC pathway involving phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt)/nuclear factor (NF) -κB pathway in RCC. (A) Representative images, (B) cell viability of RCC by MTT assay and quantitative assessment of (C) p-PI3K/PI3K, (D) p-Akt/Akt, (E) p-IκBα/IκBα and (F) p–NF–κB/NF-κB in RCC cells with or without the presence of 740 Y–P and LY294002. (B) Cell viability of RCC. Mean ± SD (n = 5). *p < 0.05, **p < 0.01 and ***p < 0.001 vs. 0 μM PAC group; #p < 0.05, ##p < 0.01 and ###p < 0.001 vs. the single PAC treated group.