Table 4.
Univariate and multivariate logistics regression analyses of CBC-derived systemic-inflammatory indices associated with sICH.
| Symptomatic ICH |
|||||||
|---|---|---|---|---|---|---|---|
| Yes (n = 50) | No (n = 432) | OR (95%CI) | P | aOR (95%CI)a | P | aPb | |
| Admission, median (IQR) | |||||||
| Neutrophil, × 109/L | 7.21(4.57–8.76) | 6.41(4.89–8.75) | 1.060(0.978–1.149) | 0.155 | 1.053(0.953–1.165) | 0.311 | Ns |
| Monocyte, × 109/L | 0.42(0.29–0.52) | 0.4(0.3–0.52) | 0.900(0.418–1.940) | 0.788 | 0.969(0.376–2.495) | 0.948 | Ns |
| Lymphocyte, × 109/L | 1.09(0.8–1.61) | 1.29(0.95–1.82) | 0.677(0.432–1.061) | 0.089 | 0.673(0.412–1.098) | 0.113 | Ns |
| Platelet, × 109/L | 199.5(158–244) | 205(170.5–245) | 0.997(0.992–1.002) | 0.186 | 0.999(0.994–1.005) | 0.832 | Ns |
| NLR | 6.72(4.02–10.57) | 5.02(2.93–7.7) | 1.032(0.999–1.067) | 0.056 | 1.032(0.994–1.071) | 0.096 | Ns |
| MLR | 0.34(0.23–0.45) | 0.3(0.21–0.4) | 1.303(0.947–1.792) | 0.104 | 1.315(0.911–1.899) | 0.144 | ns |
| PLR | 179.8(123.9–253.2) | 154.7(106.4–225.1) | 1.001(1.000–1.002) | 0.075 | 1.001(1.000–1.003) | 0.124 | ns |
| PNR | 32.1(20.24–41.79) | 31.31(22.99–42.82) | 0.987(0.968–1.007) | 0.197 | 0.990(0.970–1.011) | 0.348 | ns |
| SII | 1378(632.1–1929) | 1003(540.6–1722.9) | 1.000(1.000–1.000) | 0.329 | 1.000(1.000–1.000) | 0.225 | ns |
| SIRI | 2.29(1.24–3.58) | 1.86(1.1–3.38) | 1.023(0.993–1.055) | 0.138 | 1.025(0.990–1.060) | 0.16 | ns |
| AISI | 409.2(256.3–697.3) | 365.7(210.6–699.3) | 1.000(1.000–1.000) | 0.464 | 1.000(1.000–1.000) | 0.252 | ns |
| Day 1, median (IQR) | |||||||
| Neutrophil, × 109/L | 9.3(7.62–11.78) | 7.7(6.005–9.925) | 1.175(1.080–1.278) | <0.001 | 1.201(1.084–1.331) | <0.001 | 0.003 |
| Monocyte, × 109/L | 0.36(0.16–0.56) | 0.43(0.31–0.56) | 0.333(0.078–1.413) | 0.136 | 0.547(0.119–2.511) | 0.438 | ns |
| Lymphocyte, × 109/L | 0.69(0.44–0.97) | 1.06(0.72–1.41) | 0.305(0.149–0.622) | 0.001 | 0.338(0.159–0.717) | 0.005 | 0.056 |
| Platelet, × 109/L | 185(141–230) | 206(171–245) | 0.993(0.988–0.998) | 0.01 | 0.996(0.990–1.002) | 0.185 | ns |
| NLR | 12.67(9.65–21.24) | 7.11(4.7–11.38) | 1.092(1.059–1.127) | <0.001 | 1.107(1.064–1.151) | <0.001 | <0.001 |
| MLR | 0.54(0.22–0.83) | 0.4(0.28–0.58) | 4.042(1.925–8.489) | <0.001 | 4.898(1.964–12.22) | 0.001 | 0.006 |
| PLR | 257(196.7–400) | 196.7(138.7–280) | 1.003(1.001–1.004) | 0.001 | 1.004(1.002–1.005) | <0.001 | 0.002 |
| PNR | 19.99(14.62–25.57) | 25.91(19.87–34.97) | 0.920(0.886–0.955) | <0.001 | 0.927(0.890–0.967) | <0.001 | 0.002 |
| SII | 2639(1509–3534) | 1463(901.1–2449) | 1.000(1.000–1.000) | <0.001 | 1.000(1.000–1.000) | 0.001 | 0.005 |
| SIRI | 5.18(2.29–8.31) | 2.98(1.85–5.29) | 1.094(1.038–1.152) | 0.001 | 1.102(1.039–1.169) | 0.001 | 0.01 |
| AISI | 784.8(510.2–1462) | 592.1(350.7–1125) | 1.000(1.000–1.000) | 0.136 | 1.000(1.000–1.000) | 0.239 | ns |
Note.
Abbreviations: OR, odds ratio; aOR, adjusted odds ratio; aP, adjusted p value; CI, confidence interval; ICH, intracerebral hemorrhage; IQR, interquartile range; mRS, modified Rankin scale; ns, not significant.
a
adjustment for dyslipidemia, coronary heart disease, anticoagulants use, admission NIHSS and ASPECTS scores, groin puncture-to-recanalization time, prior IVT, anesthesia type, and the number of passes.
b
Bonferroni correction test.