Fig. 2. Representative dose–response curves of Mpro γ-lactam inhibitors used to determine IC50-values. (A) 7 (black triangles), 8 (orange circles), 16a (cyan boxes), 16b (green diamonds), 16c (violet inverse triangles), 16d (blue hexagons), and (B) 16e (blue hexagons), 16f (violet inverse triangles), 23b (green diamonds), 23c (black triangles), 23e (orange circles), 23f (cyan boxes). Two dose–response curves each composed of technical duplicates were independently determined using reported SPE-MS Mpro inhibition assays.42.
