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. 2024 May 22;22:60. doi: 10.1186/s12958-024-01233-7

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Life stage differences in the profiles of steroid hormone release rates from first (fo-1st trim.) and second (fo-2nd trim.) trimester fetal ovarian tissue cultures and adult (AO) ovarian tissue cultures. Release rates (pg/mm³/ hour) are shown on a logarithmic scale on the Y-axis. Median release rates (middle line), 25% and 75% percentiles (box borders) are shown. Mean release rates are indicated as ”+” and whiskers indicate the minimum and maximum values. N values are given in Figure S1. Statistically significant differences in steroid hormone release rates between fetal and adult ovarian cultures are shown by *(p < 0.05), **(p < 0.01) and ***(p < 0.001). < LOD, below the limit of detection.”#” used for levels of CO-SOL measured in fetal ovarian tissue cultures, which were excluded since CO-SOL was measured in the uncultured media (See in Results)